get a bunch of 100 LB or heavier stock. It'll run around $960 a 1000 sheets or so depending on what you get (contact Domtar, they are a canadian paper maker)

take the sheets to an offset printer and get them to cut them pages down to about 4" per side bigger then you need (this extra is for finger prints, registration marks, colour bars and crop marks.

print all the sheets, lightest colour to darkest.

let dry for a day or so and flatten them. Take them back to the offset printer to get trimmed (hope to hell they don't mess up the cuts)

then either get them creased, or fold them yourself. If you fold them yourself take a note as to the direction of the grain of the paper, folding with or against the grain will give different results if you don't get the paper creased or scored.

230-270 MESH on a 30"x40" frame (you are gonna need lots of room to slosh that waterbased ink around)

Speedball works, so does TW or Display

vacuum table and counterweight are necessary.

diazo emulsion is key for a project like this.

Since you don't do this all the time, you are gonna need some decent sized traps and chokes on your separations so they all line up under the key line.

it'll be fun, but in no way cheaper then sending it out to be offset printed, or sent to someone that does it all the time; in case you were wondering about costs.